Like Huntington's disease and Lewy Body disease, Pick's disease is the result of a build-up of protein in the affected areas of the brain. The accumulation of abnormal brain cells, known as Pick's bodies, eventually leads to changes in character, socially inappropriate behavior, and poor decision making, progressing to a severe impairment in intellect, memory and speech.
Pick's disease usually strikes adults between the ages of 40 and 60, and is slightly more common in women than in men. Unfortunately, the cause for Pick's disease is unknown. A few studies suggest that Pick's disease may have a genetic component, but most family members are unaffected. Other risk factors are unknown.