In contrast to Alzheimer’s disease, where memory loss is the predominate early sign, the first symptoms of Pick’s disease usually involve personality changes or a decline in basic functioning.

While the progression of symptoms in Pick's disease is fortunately slow, symptoms do worsen over time. The following symptoms are typical of patients with Pick's disease. More severe symptoms appear in later stages of the illness.

Behavioral signs and symptoms of Pick’s disease

• Impulsivity and poor judgment
• Extreme restlessness (early stages)
• Overeating or drinking to excess (when this was not previously a problem)
• Lack of attention to personal hygiene

• Sexual exhibitionism or promiscuity
• Withdrawal or decreased interest in activities of daily living
• Decline in function at work and home
• Repetitive or obsessive behavior

Emotional signs and symptoms of Pick’s disease

• Abrupt mood changes
• Lack of warmth, concern, or empathy
• Apathy

• Rudeness, impatience, or aggression
• Easily distracted; poor attention span
• Unaware of the changes in behavior

Language signs and symptoms of Pick’s disease

• Loss of vocabulary
• Trouble finding the right word
• Difficulty speaking or understanding speech
• Repeating words others say

• Weak, uncoordinated speech sounds
• Decrease in ability to read or write
• Complete loss of speech

 

Physical signs and symptoms of Pick’s disease

• Increased muscle rigidity or stiffness
• Difficulty moving about
• Lack of coordination

• General weakness
• Memory loss
• Urinary incontinence