Currently, the best methods for reaching a probable diagnosis involve careful symptomatic evaluation, together with brain scans and EEGs. These techniques can help ascertain whether the condition is likely to be Pick's disease or a related disorder such as Alzheimer's disease. Although these dementias may be similar, there are clear symptoms that set them apart.
If at least three of the following five distinguishing characteristics are present in the early stages, the diagnosis is likely to be Pick's rather than Alzheimer's. Also, as compared with Alzheimer's disease, obvious mental impairment and memory loss occur later in Pick's disease patients than in Alzheimer's patients.